well supported · human dataDiscovery of the day
In a meta-analysis of ten randomised trials, once-weekly tirzepatide reduced body weight by an average of 18.11 kg versus placebo in adults without diabetes, but by 9.06 kg in adults with diabetes, with mostly mild-to-moderate side effects in both groups.
- Study design
- Meta-analysis
- Journal
- Int J Obes (Lond)
- Evidence
- well supported
What it shows: Meta-analysis of placebo-controlled RCTs of at least 26 weeks: five trials (n=2,174) in adults with diabetes and five (n=4,467) without. The abstract does not explain why the effect differs by diabetes status.Meta-analysis · Int J Obes (Lond)
Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis. Int J Obes (Lond) 2025Read the study →