Fact of the day

Wednesday, 26 August 2026

Longevitypreliminary · human dataDiscovery of the day

Across 44 randomised trials in 4011 frail or pre-frail adults aged 60 and over, aerobic exercise improved frailty status, cognitive function, quality of life, depressive symptoms, muscle strength and lower-limb function versus usual care, with no single exercise type outperforming others.

Study design
Study
Journal
Clin Nutr
Evidence
preliminary

What it shows: Among the stronger evidence bases here: results pooled from 44 trials in 4011 older adults with frailty or pre-frailty. The studies disagreed with each other and had little data at higher exercise volumes, so the authors could not identify an optimal dose.Study · Clin Nutr

Optimal aerobic exercise dose for improving metabolic health and functional outcomes in frail older adults: A systematic review and dose-response meta-analysis. Clin Nutr 2026Read the study →

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