Fact of the day

Tuesday, 15 September 2026

Immunitywell supported · human dataDiscovery of the day

Pooled results from 15 trials in 7053 previously healthy adults and children found vitamin D3 supplements did not significantly reduce respiratory tract infections; the 6% risk reduction observed was not statistically significant.

Study design
Meta-analysis
Journal
PLoS One
Evidence
well supported

What it shows: A serious sweep of the trial evidence, but with limits: results pooled from 15 trials in 7053 people, and the trials disagreed with each other while overall quality was low. It also could not properly test whether people who are genuinely deficient in vitamin D fare differently.Meta-analysis · PLoS One

Effect of Vitamin D3 Supplementation on Respiratory Tract Infections in Healthy Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One 2016Read the study →

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