Longevitypreliminary · human dataDiscovery of the day
Pooled results from 50 randomised trials covering 4,379 adults aged 65 and over show supervised exercise modestly lowers C-reactive protein and raises the anti-inflammatory marker IL-10, while effects on other inflammatory signals such as IL-6 and TNF-α were inconsistent.
- Study design
- Study
- Journal
- Gerontologist
- Evidence
- preliminary
What it shows: About as solid as this topic gets, though modest in size: results pooled from 50 trials in 4,379 people aged 65 and over pointed the same way for C-reactive protein. Many of the underlying studies had quality problems, so the true size of the benefit is uncertain.Study · Gerontologist
Impact of supervised physical exercise on inflammatory and oxidative stress biomarkers in older adults: a systematic review and meta-analysis of randomized controlled trials. Gerontologist 2026Read the study →