Lifting alone moves cholesterol in the right direction
Strength training on its own reduced total cholesterol, triglycerides, LDL cholesterol and C-reactive protein in adults, while raising HDL cholesterol and adiponectin, in a meta-analysis of trials comparing lifting with no exercise.
Compiled by FitTools from the study cited below
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Added to Pulse 11 August 2026
- Study design
- Meta-analysis
- Evidence
- well supported
- Published
- 11 August 2026
Key takeaway
What it shows: Solid pooled evidence: results pooled from many adult trials comparing lifting alone with a group that did not train, and all six blood markers moved the right way. The shifts were small to moderate, and the search only runs to May 2017, so newer trials are missing.
Study details
- Design
- Meta-analysis
- Authors
- Costa RR, Buttelli ACK, Vieira AF, Coconcelli L, Magalhães RL, Delevatti RS, et al.
- Journal
- J Phys Act Health
- Published
- 2019
- Added to Pulse
- 11 August 2026
Why it matters
Cardiovascular risk is usually discussed in terms of aerobic exercise, while lifting gets filed under muscle and bone. Blood lipids such as total cholesterol, LDL, HDL and triglycerides, along with inflammatory markers like C-reactive protein, are central to how doctors gauge heart and metabolic risk. Whether strength training on its own, with no aerobic component at all, can shift these markers has been less clear than the case for cardio. This review pooled the trial evidence to ask exactly that question in adults.
What they did
The authors searched Embase, PubMed, Cochrane and Scopus up to May 2017 for clinical trials comparing isolated strength training against a non-training control group in adults older than 18 years. Eligible trials had to measure at least one of six blood outcomes: total cholesterol, triglycerides, LDL, HDL, C-reactive protein or adiponectin. Results were combined using a random effects model, with effects expressed as standardised mean differences. Meta-regressions were also run to explore what influenced the results.
What they found
Strength training was linked to reductions in total cholesterol, triglycerides, LDL and C-reactive protein compared with not training. It was also associated with increases in HDL and adiponectin. On the standardised scale used, the shifts ranged from small for triglycerides to moderate for LDL and C-reactive protein, with the largest change observed for adiponectin. All six outcomes moved in the direction associated with lower cardiometabolic risk, and none moved the wrong way.
Where it fits
The finding strengthens the case that resistance training earns a place in cardiometabolic health, not just in building muscle. It complements the far larger evidence base for aerobic exercise, though this review compared lifting with doing nothing rather than with cardio, so it cannot say which mode is better. The search closed in May 2017, which means trials published since are not counted. The abstract does not report which programme features drove the effects, leaving intensity, volume and duration as open questions.
What it means for you
If you already lift and skip cardio, this is a reason to think your blood lipid and inflammation profile may still be benefiting. The changes here came from strength training as the only intervention, measured against adults who did not train. It is informational rather than a prescription: the review does not say how much lifting, at what intensity, or for how long. But it adds weight to the idea that the barbell is a metabolic tool as well as a muscular one.
The source
Effect of Strength Training on Lipid and Inflammatory Outcomes: Systematic Review With Meta-Analysis and Meta-Regression. J Phys Act Health 2019
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