Creatine monohydrate

Well-supported· human data

Also known as: Creatine

The most-researched, best-evidenced supplement for strength and muscle.

What it is

Creatine is a compound your body already makes and stores in muscle, where it helps rapidly regenerate ATP — the fast energy currency for short, hard efforts. Supplementing raises muscle creatine stores above what diet alone provides. Creatine monohydrate is the original, cheapest and by far the most-studied form.

What the evidence shows

Strength, power and muscle. Well-supported· human data This is as strong as supplement evidence gets. Across a large body of human trials — summarised in the ISSN position stand — creatine reliably improves high-intensity performance and, combined with resistance training, increases strength and lean mass. It works by improving the quality of your training over weeks, not as an acute stimulant.

Cognition and other uses. Preliminary· human data There is growing but earlier evidence for benefits to cognition (especially under sleep deprivation) and other areas. Interesting, not yet settled.

Fat loss or "toning" on its own. Marketing claim Creatine doesn't burn fat. Any body-composition benefit comes indirectly, via supporting harder training and more muscle.

Who it suits

Anyone doing resistance or high-intensity training who wants a well-evidenced, low-cost edge. Vegetarians and vegans often see a slightly larger effect, as their baseline muscle creatine tends to be lower.

Practical notes

Loading is optional — a standard daily amount saturates muscle within a few weeks just as well, with less chance of stomach upset. Timing doesn't matter much; consistency does. Stick to plain monohydrate: the pricier "advanced" forms haven't been shown to beat it. Our creatine calculator helps with sensible amounts.

Sources

Frequently asked questions

Does creatine actually work?
Yes — it is the most robustly supported sports supplement there is. A large body of human trials and the ISSN position stand conclude creatine monohydrate reliably improves high-intensity performance and, with training, gains in strength and lean mass.
Do I need to load creatine?
No. Loading (a higher dose for ~5–7 days) simply fills muscle stores faster. Taking a standard daily amount reaches the same saturation within a few weeks, with less chance of stomach upset.
Is creatine safe?
In healthy people it has one of the strongest safety records of any supplement across decades of study. It draws a little water into muscle, so early weight can rise slightly. Anyone with kidney disease should check with their doctor first.
Which form is best?
Plain creatine monohydrate. The fancier, pricier forms have not been shown to beat it, and it is the form nearly all the research used.

Written and reviewed by Mathew Beale MSc Biotechnology, University of Reading.

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