Supplement · Longevity & metabolic
Ca-AKG (calcium alpha-ketoglutarate)
Also known as: Calcium alpha-ketoglutarate, AKG
A longevity-marketed metabolite with striking animal data but scant human evidence.
- Evidence
- Bronze· animal data only
- Sources cited
- 1
- Last reviewed
- 22 July 2026
Alpha-ketoglutarate (as the calcium salt, Ca-AKG) is a Krebs-cycle metabolite involved in energy and epigenetic regulation, marketed as a longevity supplement.
The excitement comes from animal studies showing improved healthspan and, in one, reduced biological-age markers in a small human pilot. But robust randomised human outcome trials are essentially absent, so its anti-ageing claims are preliminary and animal-led.