Supplement · Longevity & metabolic
Spermidine
An autophagy-inducing polyamine with promising animal data and early human hints.
- Evidence
- Bronze· animal data only
- Sources cited
- 1
- Last reviewed
- 22 July 2026
Spermidine is a polyamine, found in foods like wheat germ and aged cheese, that induces autophagy, the cell's recycling process, which is the basis for its longevity interest.
Animal studies show lifespan and cardiovascular benefits, and human observational data link higher dietary spermidine to better outcomes, with small trials hinting at memory effects. But randomised human proof of anti-ageing benefit is still lacking. Food sources are a sensible way to get it.