Supplement · Longevity & metabolic
Urolithin A
A pomegranate-derived mitophagy compound with early but genuine human muscle data.
- Evidence
- Silver· human data
- Sources cited
- 1
- Last reviewed
- 22 July 2026
Urolithin A is a compound the gut makes from pomegranate and berry polyphenols, but only in some people, depending on their microbiome, which is why it is taken directly as a supplement.
It promotes mitophagy (clearing damaged mitochondria), and unusually for this category has a few reasonable human trials suggesting improvements in muscle endurance and mitochondrial markers in older or less active adults. Promising and better-evidenced than most 'longevity' compounds, though still early.