Supplement · Joint, bone & connective tissue
MSM (methylsulfonylmethane)
Also known as: Methylsulfonylmethane
A sulphur compound with early evidence for joint pain and exercise recovery.
- Evidence
- Silver· human data
- Sources cited
- 1
- Last reviewed
- 22 July 2026
MSM is an organic sulphur compound taken for joint comfort, inflammation and, more recently, exercise recovery. Sulphur is a building block of connective tissue, which underlies the rationale.
Small trials suggest modest reductions in joint pain in osteoarthritis (sometimes combined with glucosamine) and in markers of exercise-induced muscle damage, but studies are small and short. Promising and well tolerated rather than firmly established.