5-HTP

Silver· human data

Also known as: 5-hydroxytryptophan

A serotonin precursor taken for mood and sleep, with real safety cautions.

5-HTP is a direct precursor to serotonin, one step closer than tryptophan, and is taken for mood, appetite and sleep.

Some small studies suggest benefits for low mood and sleep, but the evidence is limited and mixed. More importantly, because it raises serotonin it should not be combined with antidepressants or other serotonergic drugs, and there are theoretical concerns about long-term use — making medical advice sensible before trying it.

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Written and reviewed by Mathew Beale, MSc Biotechnology, University of Reading.

Last reviewed: